Some expressions in "Break Now the Bread of Life" may not satisfy everyone in the Reformed community, but these verses were not written to define doctrine in sharp detail. They were intended to be used as a simple prayer for illumination for Bible study groups and in the meetings of the Chautauqua Literary and Scientific Circle. Tradition also calls for the hymn's use during Sunday-evening vespers at the Lake Chautauqua' assembly grounds.
The hymn text draws on biblical images to depict Scripture's role in our lives. Stanzas 1 and 2 recall the breaking and the blessing of the bread at Jesus' feeding of the five thousand. Stanza 3 confesses Christ as the bread of life. Stanza 4 calls for the Spirit's presence and alludes to Christ's healings of various blind people.
Bert Polman, Psalter Hymnal Handbook
This song emphasizes the action of the Christian and the church to call on God to renew our hearts through the word. These requests are based on the truths taught in Belgic Confession, Article 24: True faith is “produced in us by the hearing of God’s Word and by the work of the Holy Spirit, (and) regenerates us and makes us new creatures, causing us to live a new life and freeing us from the slavery of sin.”